{"generated_at":"2026-11-09T01:13:46.553Z","nodes":[{"node_id":"SYSTEM-ECS","node_type":"BIOLOGICAL_SYSTEM","label":"Endocannabinoid system","species":null,"description_plain":"A signalling network found across mammals that uses internally produced cannabinoids, receptors and metabolic enzymes to influence processes including nerve signalling, immune activity and homeostasis.","canonical_id":null,"evidence_status":"ESTABLISHED_BACKGROUND"},{"node_id":"DATA-GSE12195","node_type":"DATASET","label":"GSE12195","species":"Homo sapiens","description_plain":"Human lymphoma gene-expression dataset used in ARCHIE-000.","canonical_id":"GEO:GSE12195","evidence_status":"VALIDATED"},{"node_id":"DATA-GSE30881","node_type":"DATASET","label":"GSE30881","species":"Canis lupus familiaris","description_plain":"Canine lymphoma gene-expression dataset used in 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sapiens","experiment_id":"ARCHIE-000","evidence_type":"DATASET","evidence_strength":"DIRECT","source_url":"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE12195","source_title":"GSE12195","notes_plain":"Human expression dataset analysed in ARCHIE-000."},{"edge_id":"EDGE-0003","from_node_id":"GENE-BCL6","relationship":"conserved_signal_between","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"BCL6 was among the strict conserved dog-human signals."},{"edge_id":"EDGE-0004","from_node_id":"GENE-BCL6","relationship":"conserved_signal_between","to_node_id":"SPECIES-HUMAN","species":"Homo sapiens","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"BCL6 was among the strict conserved dog-human signals."},{"edge_id":"EDGE-0005","from_node_id":"GENE-LCK","relationship":"conserved_signal_between","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"LCK was among the strict conserved dog-human signals."},{"edge_id":"EDGE-0006","from_node_id":"GENE-LCK","relationship":"conserved_signal_between","to_node_id":"SPECIES-HUMAN","species":"Homo sapiens","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"LCK was among the strict conserved dog-human signals."},{"edge_id":"EDGE-0007","from_node_id":"GENE-CD38","relationship":"conserved_signal_between","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"CD38 was among the strict conserved dog-human signals."},{"edge_id":"EDGE-0008","from_node_id":"GENE-CD38","relationship":"conserved_signal_between","to_node_id":"SPECIES-HUMAN","species":"Homo sapiens","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"CD38 was among the strict conserved dog-human signals."},{"edge_id":"EDGE-0009","from_node_id":"GENE-FGFR2","relationship":"conserved_signal_between","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"FGFR2 was the highest-ranked strict conserved signal in ARCHIE-000A."},{"edge_id":"EDGE-0010","from_node_id":"GENE-FGFR2","relationship":"conserved_signal_between","to_node_id":"SPECIES-HUMAN","species":"Homo sapiens","experiment_id":"ARCHIE-000","evidence_type":"COMPUTATIONAL","evidence_strength":"ARCHIE_VALIDATED","source_url":null,"source_title":"ARCHIE-000","notes_plain":"FGFR2 was the highest-ranked strict conserved signal in ARCHIE-000A."},{"edge_id":"EDGE-0011","from_node_id":"PATHWAY-CELL-CYCLE","relationship":"recovered_in","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"BLIND_REPLICATION","evidence_strength":"VALIDATED","source_url":null,"source_title":"ARCHIE-000C","notes_plain":"Cell-cycle biology was independently recovered before comparison with the published benchmark."},{"edge_id":"EDGE-0012","from_node_id":"PATHWAY-DNA-REPLICATION","relationship":"recovered_in","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"BLIND_REPLICATION","evidence_strength":"VALIDATED","source_url":null,"source_title":"ARCHIE-000C","notes_plain":"DNA replication was independently recovered in the blind validation."},{"edge_id":"EDGE-0013","from_node_id":"PATHWAY-DNA-REPAIR","relationship":"recovered_in","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"BLIND_REPLICATION","evidence_strength":"VALIDATED","source_url":null,"source_title":"ARCHIE-000C","notes_plain":"DNA repair was independently recovered in the blind validation."},{"edge_id":"EDGE-0014","from_node_id":"PATHWAY-TCELL","relationship":"recovered_in","to_node_id":"SPECIES-DOG","species":"Canis lupus familiaris","experiment_id":"ARCHIE-000","evidence_type":"BLIND_REPLICATION","evidence_strength":"VALIDATED","source_url":null,"source_title":"ARCHIE-000C","notes_plain":"T-cell activation was independently recovered in the canine analysis."},{"edge_id":"EDGE-ECS-001","from_node_id":"MOLECULE-AEA","relationship":"component_of","to_node_id":"SYSTEM-ECS","species":null,"experiment_id":null,"evidence_type":"ESTABLISHED_BIOLOGY","evidence_strength":"BACKGROUND","source_url":"https://pubmed.ncbi.nlm.nih.gov/39162768/","source_title":"Endocannabinoid system and phytocannabinoids in the main species of veterinary interest","notes_plain":"Anandamide is an endogenous signalling molecule within the endocannabinoid system."},{"edge_id":"EDGE-ECS-002","from_node_id":"MOLECULE-2AG","relationship":"component_of","to_node_id":"SYSTEM-ECS","species":null,"experiment_id":null,"evidence_type":"ESTABLISHED_BIOLOGY","evidence_strength":"BACKGROUND","source_url":"https://pubmed.ncbi.nlm.nih.gov/39162768/","source_title":"Endocannabinoid system and phytocannabinoids in the main species of veterinary interest","notes_plain":"2-AG is a major endogenous signalling molecule within the endocannabinoid system."},{"edge_id":"EDGE-ECS-003","from_node_id":"GENE-CNR1","relationship":"encodes_receptor_in","to_node_id":"SYSTEM-ECS","species":null,"experiment_id":null,"evidence_type":"ESTABLISHED_BIOLOGY","evidence_strength":"BACKGROUND","source_url":"https://pubmed.ncbi.nlm.nih.gov/39162768/","source_title":"Endocannabinoid system and phytocannabinoids in the main species of veterinary interest","notes_plain":"CNR1 encodes the CB1 cannabinoid receptor."},{"edge_id":"EDGE-ECS-004","from_node_id":"GENE-CNR2","relationship":"encodes_receptor_in","to_node_id":"SYSTEM-ECS","species":null,"experiment_id":null,"evidence_type":"ESTABLISHED_BIOLOGY","evidence_strength":"BACKGROUND","source_url":"https://pubmed.ncbi.nlm.nih.gov/39162768/","source_title":"Endocannabinoid system and phytocannabinoids in the main species of veterinary interest","notes_plain":"CNR2 encodes the CB2 cannabinoid receptor."},{"edge_id":"EDGE-ECS-005","from_node_id":"PHYTO-THC","relationship":"interacts_with","to_node_id":"GENE-CNR1","species":null,"experiment_id":"ARCHIE-SCOUT-002","evidence_type":"BACKGROUND_PHARMACOLOGY","evidence_strength":"ESTABLISHED","source_url":"https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq","source_title":"Cannabis and Cannabinoids (PDQ) - Health Professional Version","notes_plain":"THC can interact with cannabinoid receptors including CB1. This edge does not imply anticancer efficacy."},{"edge_id":"EDGE-ECS-006","from_node_id":"PHYTO-THC","relationship":"interacts_with","to_node_id":"GENE-CNR2","species":null,"experiment_id":"ARCHIE-SCOUT-002","evidence_type":"BACKGROUND_PHARMACOLOGY","evidence_strength":"ESTABLISHED","source_url":"https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq","source_title":"Cannabis and Cannabinoids (PDQ) - Health Professional Version","notes_plain":"THC can interact with cannabinoid receptors including CB2. This edge does not imply anticancer efficacy."},{"edge_id":"EDGE-ECS-007","from_node_id":"PHYTO-CBD","relationship":"modulates","to_node_id":"SYSTEM-ECS","species":null,"experiment_id":"ARCHIE-SCOUT-002","evidence_type":"BACKGROUND_PHARMACOLOGY","evidence_strength":"ESTABLISHED","source_url":"https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq","source_title":"Cannabis and Cannabinoids (PDQ) - Health Professional Version","notes_plain":"CBD can influence cannabinoid-related and other signalling mechanisms. Its pharmacology is not adequately described as simple direct CB1 or CB2 activation."}],"gaps":[{"gap_id":"GAP-CANNABINOID-FELINE-001","title":"Feline cannabinoid-cancer intervention evidence","species_present":["Homo sapiens","Canis lupus familiaris"],"species_missing":["Felis catus"],"target_node_id":"PHYTO-CBD","relationship":"tested_against_cancer","rationale_plain":"SCOUT-002 identified tumour-directed cannabinoid evidence in humans and dogs but no direct feline cannabinoid-cancer intervention evidence. ARCHIE-GAP-CHALLENGE-001 then ran 32 targeted PubMed searches designed to disprove this apparent gap. Only two candidates were found, neither representing a direct feline cannabinoid-cancer intervention experiment. This remains an evidence gap, not proof that no such experiment exists. Additional dataset and registry searches are required.","status":"PUBMED_CHALLENGE_SURVIVED","confidence":"MODERATE","experiment_id":"ARCHIE-SCOUT-002"}]}