[
  {
    "pmid": "18286801",
    "url": "https://pubmed.ncbi.nlm.nih.gov/18286801/",
    "title": "Cannabinoids in health and disease.",
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    "pmid": "21993992",
    "url": "https://pubmed.ncbi.nlm.nih.gov/21993992/",
    "title": "Understanding abdominal ultrasonography in horses: which way is up?",
    "roles_mentioning": [
      "SCEPTIC"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "rejected: equine imaging does not support canine oncology",
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    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "30019449",
    "url": "https://pubmed.ncbi.nlm.nih.gov/30019449/",
    "title": "Anti-tumour actions of cannabinoids",
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      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER"
    ],
    "identity_check": "matched PubMed identifier and title",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "34294753",
    "url": "https://pubmed.ncbi.nlm.nih.gov/34294753/",
    "title": "Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations",
    "roles_mentioning": [
      "SCEPTIC"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "34326138",
    "url": "https://pubmed.ncbi.nlm.nih.gov/34326138/",
    "title": "Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2)",
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      "SCEPTIC"
    ],
    "identity_check": "matched PubMed identifier and title",
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    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "35242839",
    "url": "https://pubmed.ncbi.nlm.nih.gov/35242839/",
    "title": "Circulating Endocannabinoids in Canine Multicentric Lymphoma Patients.",
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      "GAP_FINDER",
      "SCEPTIC",
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    "identity_check": "matched PubMed identifier and title",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "37046779",
    "url": "https://pubmed.ncbi.nlm.nih.gov/37046779/",
    "title": "Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment",
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      "GAP_FINDER",
      "SCEPTIC",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "37330042",
    "url": "https://pubmed.ncbi.nlm.nih.gov/37330042/",
    "title": "Validating the anti-lymphoma pharmacodynamic actions of the endocannabinoids on canine non-Hodgkin lymphoma",
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      "GAP_FINDER",
      "SCEPTIC",
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    ],
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    "claim_review": "checked for laboratory setting; endocannabinoids are not CBD",
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    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "38672512",
    "url": "https://pubmed.ncbi.nlm.nih.gov/38672512/",
    "title": "Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines",
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      "CROSS_SPECIES_ANALYST",
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      "EXPERIMENT_DESIGNER",
      "TRANSLATOR"
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    "identity_check": "matched PubMed identifier and title",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "39299090",
    "url": "https://pubmed.ncbi.nlm.nih.gov/39299090/",
    "title": "Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma: An immunohistochemical, digital pathology and clinical analysis.",
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    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "39539239",
    "url": "https://pubmed.ncbi.nlm.nih.gov/39539239/",
    "title": "Drug Interactions in People on Cannabidiol: Is There Cause for Concern?",
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    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "39739175",
    "url": "https://pubmed.ncbi.nlm.nih.gov/39739175/",
    "title": "The Role of Cannabinoids and the Endocannabinoid System in the Treatment and Regulation of Nausea and Vomiting",
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    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "40370489",
    "url": "https://pubmed.ncbi.nlm.nih.gov/40370489/",
    "title": "The endocannabinoid system in cancer biology: a mini-review of mechanisms and therapeutic potential",
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      "GAP_FINDER",
      "SCEPTIC",
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    "identity_check": "matched PubMed identifier and title",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "40622742",
    "url": "https://pubmed.ncbi.nlm.nih.gov/40622742/",
    "title": "Safety, Efficacy and Doxorubicin Pharmacokinetics During Cannabidiol/Cannabidiolic Acid Rich Hemp Oil Use in Dogs With Lymphoma Undergoing CHOP Chemotherapy",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "EXPERIMENT_DESIGNER",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "checked for canine population and pharmacokinetic setting",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "40968477",
    "url": "https://pubmed.ncbi.nlm.nih.gov/40968477/",
    "title": "Cats and cannabinoids: past, present and future.",
    "roles_mentioning": [
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      "GAP_FINDER",
      "SCEPTIC",
      "EXPERIMENT_DESIGNER",
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    ],
    "identity_check": "matched PubMed identifier and title",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41288593",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41288593/",
    "title": "Cannabidiol in Gliomas: Therapeutic Potential and Nanocarrier Strategies, with an Emphasis on Vesicular Delivery Systems",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
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    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41296368",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41296368/",
    "title": "Therapeutic Use of Cannabis and Cannabinoids: A Review.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41429435",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41429435/",
    "title": "Liver enzyme effects of medicinal cannabis in advanced cancer: a substudy of two randomised trials.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41595541",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41595541/",
    "title": "Cytotoxicity of Cannabinoids in Combination with Traditional Lymphoma Chemotherapeutic Drugs Against Non-Hodgkin's Lymphoma",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "EXPERIMENT_DESIGNER",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41633759",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41633759/",
    "title": "Cannabinoids and drug-drug pharmacokinetic interactions: Deciphering the risks.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "EXPERIMENT_DESIGNER",
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    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41670942",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41670942/",
    "title": "Pharmacokinetic studies and synergistic antitumor effects of cannabichromene and cannabidiol in drug-resistant breast cancers.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41751466",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41751466/",
    "title": "In Silico Molecular Docking and Pharmacokinetic Evaluation of Cannabinoid Derivatives as Multi-Target Inhibitors for EGFR, VEGFR-1, and VEGFR-2 Proteins.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
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    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "41827696",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41827696/",
    "title": "Cannabinoids in Combination with Conventional Breast Cancer Therapies: Mechanistic Insights and the Gap to Clinical Translation",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
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    "pmid": "42050177",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42050177/",
    "title": "Evaluation of dronabinol to decrease opioid use for cancer-induced bone pain.",
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      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "checked for the limited single-arm opioid-use claim",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42076122",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42076122/",
    "title": "Cannabinoids for Dermatological Applications: Mechanistic Insights, Clinical Evidence, and Emerging Nanotechnology-Enabled Delivery Strategies.",
    "roles_mentioning": [
      "GAP_FINDER"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42085369",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42085369/",
    "title": "Cannabinoids in the Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review of Randomized Controlled Trials.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42137120",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42137120/",
    "title": "Cannabidiol-Induced Tumor Cell Death: Molecular Mechanisms and Translational Perspectives in Cancer Therapy.",
    "roles_mentioning": [
      "SCEPTIC",
      "EXPERIMENT_DESIGNER",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42254894",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42254894/",
    "title": "Potential antitumor effect of cannabidiol (CBD) in canine oncology: a systematic review",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42476829",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42476829/",
    "title": "Phase I/II Double-Blind, Randomized Controlled Trial of Medicinal Cannabis on Quality of Life and Symptoms in Advanced Cancer: RESONANCE Trial Protocol.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "protocol only: not an efficacy outcome",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42661582",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42661582/",
    "title": "Cannabidiol Suppresses Glioma Growth and Limits Invasion Partly Through an LOXL2-Associated EMT-Like Program",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER",
      "SCEPTIC",
      "TRANSLATOR"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
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    "pmid": "42737454",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42737454/",
    "title": "Medical Cannabis and the Hallmarks of Cancer: A Critical Narrative Review.",
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      "GAP_FINDER",
      "SCEPTIC",
      "TRANSLATOR"
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    "identity_check": "matched PubMed identifier and title",
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    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
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    "pmid": "42750778",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42750778/",
    "title": "Cannabidiol for anxiety and depressive symptoms in primary brain tumors: Results from an early-terminated, placebo-controlled, crossover randomized clinical trial.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "SCEPTIC"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
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    "pmid": "42755980",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42755980/",
    "title": "Targeting pancreatic cancer with natural compounds: molecular mechanisms, preclinical evidence, clinical perspectives, and limitations.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST",
      "GAP_FINDER"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  },
  {
    "pmid": "42767994",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42767994/",
    "title": "Dose response relationship of medical cannabis and symptom control in patients with pancreatic cancer: an analysis of the CANPAN trial.",
    "roles_mentioning": [
      "CROSS_SPECIES_ANALYST"
    ],
    "identity_check": "matched PubMed identifier and title",
    "claim_review": "not adjudicated",
    "original_role_packet_membership": "not established",
    "validation_state": "NOT_PROMOTED"
  }
]